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Furthermore, cells in several types of cancers are characterized by significant enhancement of glutathione biosynthesis, and this metabolic vulnerability has been targeted to sensitize these cancer cells to ROS-induced drugs 63

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Antibody effector assays By common definition, neutralization assays include only virus, antibody and target cell but, in vivo, several other factors could contribute to the antiviral activity of nAbs by recognizing clusters of nAbs bound to antigen on virions or infected cells (Fig